• Introduction Determining how genes function together as

  2020-01-06

  

  Introduction Determining how genes function together as biological systems is a defining challenge of the genomic era. While genome sequences reveal the DNA blueprint of organisms, deciphering how this blueprint leads to biological function is challenging due in large part to the complexity of prot

• Some studies have integrated the use of cloud computing with

  2020-01-06

  

  Some studies have integrated the use of cloud computing with user interfaces in the domain of our proposal (i.e. UI). In [24] the authors work with Android devices to achieve more flexibility in the user interfaces by making use of information about the environment (for example, with an ambient ligh

• The repeat sequence TTAGGG of telomere could

  2020-01-06

  

  The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere JNJ-26481585 mg structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncapping, which ef

• Because sex steroids and growth

  2020-01-06

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

• harmine hydrochloride br Materials and methods br

  2020-01-03

  

  Materials and methods Results Discussion CDK and their regulatory cyclins form a family of heterodimeric kinases that are particularly important for regulation of harmine hydrochloride progression and transcription in tumor cells. These kinases therefore constitute biomarkers of proliferati

• The radial distribution function is

  2020-01-03

  

  The radial distribution function, , is given by: For pure components and pseudo-components, the constants a and b are calculated as:whereand Tc, Pc and ω are the critical temperature, critical pressure and acentric factor, respectively. Parameters a and b for mixtures are calculated from those of

• br Acknowledgements This work was supported by

  2020-01-03

  

  Acknowledgements This work was supported by the European Committee Fifth Framework Project QLK5-1999-01360. We are grateful to Dr. T.T. Hoang for the provision of plasmids pEX18Tc, pPS858 and pFLP2, Prof. B.L. Wanner for providing us with the plasmid pKD4 and related strains, and Prof. P. Soucail

• br Acknowledgements br Introduction Protein tyrosine phospho

  2020-01-03

  

  Acknowledgements Introduction Protein–tyrosine phosphorylation, catalyzed by protein–tyrosine kinases and protein–tyrosine phosphatases, has a pivotal role in the regulation of a wide variety of cellular processes. Similar numbers of tyrosine kinases and tyrosine phosphatases are encoded by th

• We next turned our attention to

  2020-01-03

  

  We next turned our attention to the 6-position of the indole (). It was found that the chlorine atom present in was extremely important. The des-chloro analogue showed nearly 30-fold less affinity for the EP receptor in the binding assay and was nearly 30-fold lower in activity in the functional ass

• br Results and discussion The effects of hypoxia a

  2020-01-03

  

  Results and discussion The effects of hypoxia, a combination of shear stress and hyperoxia, and a combination of shear stress and hypoxia in BAECs were assessed at 0, 15, 30, 60, 120, and 180 min. Changes in phosphorylation levels of eNOS at Ser635 were investigated using immunoblotting, and repr

• br Acknowledgments br Introduction br Endothelin receptors S

  2020-01-03

  

  Acknowledgments Introduction Endothelin receptors Shortly after the discovery of ET‐1, two types of seven transmembrane G protein‐coupled receptors were cloned called endothelin receptor A (ETA) (Arai et al., 1990) and ETB (Sakurai et al., 1990). The affinity of the ETA receptor for ET-3 is

• br Clinical potential of ET receptor biased ligands Is

  2020-01-03

  

  Clinical potential of ET receptor biased ligands Is there a clinical need for ET receptor biased ligands? Evidence is strongest from research in epithelial ovarian cancer demonstrating that ET-1 stimulated ETA-mediated β-arrestin signalling leads to activation of the oncogenic mediator NF-κB [21]

• br Effects of culture conditions on

  2020-01-03

  

  Effects of culture conditions on drug-induced gene Regorafenib hydrochloride in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that

• Early diagnosis of CVS and DCI

  2020-01-02

  

  Early diagnosis of CVS and DCI is a key issue in the management of SAH patients. In this regard, CT Perfusion (CTP) is the most accurate and sensitive method for noninvasive imaging assessment of cerebral ischemia with a great value for prediction and early diagnosis of CVS and DCI. CTP is a relativ

• br Introduction As a serine proteinase and a sub family

  2020-01-02

  

  Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino Dyngo-4a residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist, 1997) r

15309 records 932/1021 page Previous Next First page 上5页 931932933934935 下5页 Last page