• br RINGs as activators of E Ub In contrast to

  2020-08-04

  

  RINGs as activators of E2~Ub In limonin mg to HECT-type E3 ligases, RING-type E3s lack a bona fide catalytic center. A lingering question in the field has been whether RINGs serve solely to position E2~Ub relative to the substrate, or if they also serve as activators of E2~Ub. Clearly, unwanted

• Initially the doxorubicin fluorescence assay demonstrated th

  2020-08-04

  

  Initially, the doxorubicin fluorescence assay demonstrated that NU7441 induces doxorubicin accumulation in a concentration-dependent manner in paired wild-type and MDR1-overexpressing MDCKII cells. The kinase inhibitor sorafenib is used to treat advanced renal cell carcinoma [33] and hepatocellular

• EI1 Besides chemopreventive effects against oxidative DNA

  2020-08-04

  

  Besides chemopreventive effects against oxidative DNA damage we evaluated the protective effects of the three Hypericum sp. and isolated compounds against alkylating DNA damage induced by MMS in HT29 cells. Human exposure to alkylating agents, from different sources, occurs in a continuous way and i

• In rats exposed to day

  2020-08-03

  

  In rats exposed to 1 day of nicotine withdrawal (24 h after the last nicotine administration) we expected a decrease of general locomotor activity and a decrease of global striatal dopamine release, which were assessed in a previous study following 14 days of nicotine exposure and 24 h of nicotine w

• According to Graeff Graeff innate fear is mediated

  2020-08-03

  

  According to Graeff (Graeff, 1990), innate fear is mediated by neural circuitry that consists of at least the amygdala, medial hypothalamus and periaqueductal grey matter. In particular, the BLA has been considered to be a structure closely related to emotional responses to fear, stress and anxiety

• From the same perspective previous studies by

  2020-08-03

  

  From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th

• br Introduction The covalent attachment

  2020-08-03

  

  Introduction The covalent attachment of ubiquitin (Ub) to substrates plays a central role in regulating a broad range of biological processes in eukaryotes [1], [2]. Substrates can be modified with a single Ub (monoubiquitination) or with varying types of polyubiquitin chains (polyubiquitination)

• Introduction Ubiquitylation is a post

  2020-08-03

  

  Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti

• Histological examination has been the traditional means

  2020-08-03

  

  Histological examination has been the traditional means for diagnosis. Microscopic imaging of small, round, blue INCB3344 accompanied by positive CD99 antigen expression supports a diagnosis of ES. CD-99 is a 32-kDa cell membrane glycoprotein which may inhibit cellular differentiation in ES via mod

• Acute AR activation enhances cardiac contraction ionotropy a

  2020-08-03

  

  Acute β-AR activation enhances cardiac contraction (ionotropy) and relaxation (lusitropy), in large part by increasing myocyte Ca transients and accelerating [Ca]i reuptake by the sarcoplasmic reticulum (SR). These effects are mainly produced by PKA-dependent phosphorylation of L-type Ca Nilvadipine

• In this work we aimed

  2020-07-31

  

  In this work, we aimed to deepen our knowledge on the functional regulation of the malin–laforin complex. First, we focused our attention on the E2-conjugase that participates in the ubiquitination reaction. We found that the ubiquitin conjugating enzyme E2-N (UBE2N; Ubc13), one of the more than 38

• In this review we will discuss

  2020-07-31

  

  In this review, we will discuss a wide spectrum of E3 ligases that have been implicated in the pathogenesis of B-cell malignancies (Fig. 1 and Table 1). Concluding remarks BCL6, BCL2, and c-MYC are TPCA-1 oncogenes deregulated by chromosomal rearrangement and missense mutations in lymphoma arisi

• As mentioned above all DNA primases lack proofreading capaci

  2020-07-31

  

  As mentioned above, all DNA primases lack proofreading capacity. This seems advantageous for the efficient synthesis of short-lived Okazaki fragments. Conversely, the 3′-5′ exonuclease-proofreading activity, which is necessary for faithful DNA replication, could hinder the primase capacity. Thus, pi

• Though limited to a large cohort of self

  2020-07-31

  

  Though limited to a large cohort of self-reported healthy individuals, associations between individual Flavin adenine dinucleotide have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-pred

• In order to produce non diffusible

  2020-07-30

  

  In order to produce non-diffusible chelates that might be suited for use in solid (agar) media, the series of 6,7-dibromo-2,3-dihydroxynaphthalene substrates 18b, 20b, 24b and 26b were prepared (Table 3) with the expectation that the incorporation of the bromine substituents would reduce the solubil

15317 records 830/1022 page Previous Next First page 上5页 826827828829830 下5页 Last page