• Apelin is a peptide hormone

  2025-01-14

  

  Apelin is a peptide hormone and an endogenous ligand for a G protein-coupled receptor named APJ [7], [8], and apelin and APJ are widely expressed in human organs including hypothalamus, heart, lungs, kidneys, adipose tissue, muscles, and others [9]. Apelin is initially synthesized as a 77-amino-acid

• br Experiment br Results and discussion br Conclusion

  2025-01-13

  

  Experiment Results and discussion Conclusion Introduction Tuberculosis (TB) is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis [1]. TB remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after

• Actinonin peptide deformylase There are several reports abou

  2025-01-13

  

  There are several reports about the expression of AChRs and their modulation to osteogenic factors in osteoblasts (Rothem et al., 2011, Sato et al., 2010, Walker et al., 2001). The normal osteocytic MLO-Y4 Actinonin peptide deformylase expressed multiple subtypes, which was demonstrated by the dete

• Osteocytes the most abundant cells

  2025-01-13

  

  Osteocytes, the most abundant cells in an adult skeleton, are essentially mature osteoblasts that are surrounded by the products they secreted (Noble and Reeve, 2000). Osteocytes serve as mechanosensors that direct bone remodeling and that regulate the activities of osteoblasts and osteoclasts (Bone

• br Animals Female Sprague Dawley SD rats aged months

  2025-01-13

  

  Animals Female Sprague Dawley (SD) rats, aged 3 months with body weight between 180-210 g were housed in cages and acclimatized to standardized lab conditions (temperature 23 ± 2°C, humidity 50 ± 5% and 12 h light-dark cycles). The rats were fed with standard rodent food pellet (Harlan Diet, Ross

• In liver the essential organ of

  2025-01-13

  

  In liver, the essential organ of lipoprotein synthesis, ACL plays a fundamental role in lipogenesis and steroidogenesis by supplying cytosolic kt 4 to both pathways. By using a tricarboxylic acid cycle intermediate (citrate) to produce acetyl CoA, ACL can be seen as an important bridge between carb

• WKY and SHR strains have important differences mainly

  2025-01-10

  

  WKY and SHR strains have important differences mainly in their sympathetic status but also in the activity of the RAS. The development of hypertension in SHR is clearly related to an increase in sympathetic activity [51], [11]. In addition, increased renal sympathetic nerve activity led to an increa

• br Conflict of interest statement br Introduction

  2025-01-10

  

  Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant Heparin sodium like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic aldehydes contained in

• Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A

  2025-01-10

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

• Adiponectin is an adipokine whose circulating level is deple

  2025-01-10

  

  Adiponectin is an adipokine whose circulating level is depleted in a number of metabolic diseases including insulin resistance, diabetes and cancer (Khan et al., 2015, Singh et al., 2014a, Singh et al., 2014b, Yamauchi et al., 2014). Despite its importance in health and pathophysiology, adiponectin

• The central problem in amnesia developing following impairme

  2025-01-10

  

  The central problem in amnesia developing following impairment of long-term memory consolidation or reconsolidation is a question of the underlying mechanisms, whether it is caused by impairment of retrieval or memory storage mechanisms [3,8,9,[15], [16], [17], [18]]. To answer this question, severa

• ADORs accomplish a variety of physiological effects in diffe

  2025-01-10

  

  ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.

• br Experimental section br Results and discussion br Conclus

  2025-01-10

  

  Experimental section Results and discussion Conclusions We present a simple, sensitive and selective assay of ADA activity and its inhibitor using the enzyme catalyzed reaction and the different interaction intensity of dye-labeled AD aptamer, aptamer/AD complex with GO. The as-proposed met

• br Introduction In myasthenia gravis MG autoantibodies again

  2025-01-10

  

  Introduction In myasthenia gravis (MG), autoantibodies against the native AChR conformation cause loss of AChR at the neuromuscular junction and fatigable muscle weakness (Newsom-Davis et al., 1993). The AChR is a pentameric transmembrane protein, with two splice forms of the α-subunit, P3A− and

• br Role of LPA in tumor

  2025-01-09

  

  Role of LPA in tumor angiogenesis and skeletal metastasis The angiogenesis switch is essential for tumor expansion and escape of tumor trpv1 from the primary site and forming distant metastases. Evidence for the role of LPA2 and LPA3 in the mobility of endothelial cells and the formation of neo-v

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