• After initial validation of the

  2021-12-28

  

  After initial validation of the ability of Ad5-Cre virus to express Cre recombinase protein in glial cells in vitro and in vivo, we employed this virus to induce site-specific deletion of our target GlyT1 in the thalamus, through injection of the cKO GlyT1 mice. This transgenic line was constructed

• br Glycoengineering br The Omics perspective The publication

  2021-12-28

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO 5α-dihydro-11-keto Testosterone receptor for im

• br Cell origin The ontogeny of astrocytes in vitro

  2021-12-28

  

  Cell origin The ontogeny of astrocytes in vitro has been investigated in detail; Raff et al. (1983) characterised two types of astrocytes: type 1 being fibroblast-like in morphology and poorly labelled with a monoclonal antibody (AB25), whereas type 2 exhibited oligodendrocyte or neuron-like morp

• br Discussion RBCs possess a

  2021-12-27

  

  Discussion RBCs possess a much simpler composition and structure than other eukaryotic bosentan and can therefore serve as a convenient system on which to study how cell functioning relates to the molecular and supramolecular properties of its constituents. The model developed in this work is ai

• br Ethics statements br Introduction

  2021-12-27

  

  Ethics statements Introduction Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor and the third leading cause of cancer-related mortality worldwide, with rapidly-increasing incidence in recent years [1,2]. Mounting evidence shows that viral hepatitis, toxin exposure, non-a

• br Place in Therapy In the case of minor

  2021-12-27

  

  Place in Therapy In the case of minor bleeding, the anticoagulant effects of all FXa inhibitors except betrixaban, which has a longer half-life, will diminish within 24-48 hours of discontinuation of the drug provided the patient has normal renal function. In these cases stopping the FXa inhibito

• We examined the expression of notch in the brains

  2021-12-27

  

  We examined the expression of notch-1 in the brains of mice following morphine or oxycodone tolerance. The results showed that notch-1 levels did not change following morphine or oxycodone tolerance, with or without the treatment of IRL-1620. This indicates the possibility that morphine or oxycodone

• br Mammalian chromosomal DNA binds to various proteins and t

  2021-12-27

  

  Mammalian chromosomal DNA binds to various proteins and the DNA-protein complexes form DNA packaging units, called nucleosomes. Histones are the chief protein components of nucleosomes and perform pivotal functions in chromosomal gene regulation. Moreover, many types of chemical modifications of h

• In mammalian cells Motins have been identified

  2021-12-27

  

  In mammalian cells, Motins have been identified as a key link between F-actin and Hippo pathway regulation, as knockdown of all three Motins increased Yap activity even in the presence of cytoskeletal disruption [105]. Motins can physically associate with F-actin but this association is blocked by p

• An important aspect of macrophage biology

  2021-12-27

  

  An important aspect of macrophage biology, highly influenced by HO-1 activity, is macrophage polarization. The broadest classification, based on the in vitro stimulation, surface marker expression, and inflammatory cytokines production, describes macrophages as classically activated, proinflammatory

• Camptothecin is a type of topo I

  2021-12-27

  

  Camptothecin is a type of topo I inhibitor, and its prodrugs irinotecan and topotecan have been approved by the FDA for clinical cancer treatment. It has been reported that SAHA can enhance the cytotoxicity of camptothecin derivatives in several cancer cell lines20., 21., 22., 23., 24.. Taking the s

• Accessibility and physico chemical features of cysteine resi

  2021-12-27

  

  Accessibility and physico-chemical features of cysteine residues define their redox-reactivity and the 3-dimensional structure of GSNOR allows to identifying such surface-exposed, redox-sensitive cysteine residues. GSNOR crystal structures are available from human (Protein Data Bank code: 1MP0), tom

• Further our study provides the first evidence that

  2021-12-27

  

  Further, our study provides the first evidence that zaprinast and kynurenic GW-1100 administration not only prevented the development of thermal and mechanical hypersensitivity but also enhanced morphine antinociceptive properties. Morphine is considered to be one of the most effective analgesic dr

• The results of our study indicate the general

  2021-12-27

  

  The results of our study indicate the general importance of the gp120 V3 loop NB-598 hydrochloride patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with respect to

• To further investigate the molecular mechanisms

  2021-12-27

  

  To further investigate the molecular mechanisms that underlie glycine's β-cell protective effects through its antioxidative activity in diabetes, we used a H2O2/high glucose-induced apoptosis cell model. Similar effects on ROS generation of high glucose and H2O2 support the in vivo results, suggesti

15414 records 555/1028 page Previous Next First page 上5页 551552553554555 下5页 Last page