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In conclusion atorvastatin but not pravastatin impaired gluc
2021-12-08
In conclusion, atorvastatin but not pravastatin impaired glucose utilization in C2C12 cells and glucose tolerance in HFD mice, which may be partly due to the inhibition of GLUT4 translocation in muscle cells. The decrease in the cholesterol level induced by atorvastatin may partly account for the in
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Epinephrine responses to hypoglycemia are probably triggered
2021-12-08
Epinephrine responses to hypoglycemia are probably triggered centrally, perhaps with input from peripheral hypoglycemia sensing [3], [4]. We observed increased epinephrine responses in GCK-MODY and I366F diabetic mice. Consistent with a role for Dronedarone GCK in detecting a low blood glucose, we
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The findings in this study may
2021-12-08
The findings in this study may represent an example of a more general phenomenon, namely that the exquisite specificity of the G protein-coupled receptors that mediate the physiological actions of the selective serotonin reuptake inhibitors family hormones in mammals may have arisen relatively late
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In the second part of this study we investigated
2021-12-08
In the second part of this study, we investigated the influence of GH on the SKF 86002 dihydrochloride of the ghrelin receptor, GHSR-1a, at the mRNA and peptide levels in cultured whole follicles. Regulation of the expression of GHSR-1a has a key role in the actions of ghrelin in target tissues. Usi
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Previously we have shown that ghrelin and cannabinoids stimu
2021-12-08
Previously, we have shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity (Kola et al., 2005). In contrast, both the orexigenic compounds have inhibitory effects on AMPK activity in the liver and visceral fat (Kola et al., 2005). In this study, we were able to reproduce our previo
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One way to approach this
2021-12-08
One way to approach this unifying hypothesis will be to compare the effects of the PBR/VDAC ligands on these processes. Recent studies have demonstrated that the three ligands of peripheral-type benzodiazepine receptor, i.e. PK 11195, Ro5-4864 and diazepam reduce membrane transport and conductance i
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Bile acids BAs are critical for facilitating the absorption
2021-12-08
Bile acids (BAs) are critical for facilitating the Endoxifen of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, and vitamin D
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Apoptosis via Fas FasL system has been evidenced to
2021-12-08
Apoptosis via Fas/FasL system has been evidenced to play a role in the pathogenesis of many diseases [26], [27], [28], [29], [30], [31], [32], [33], [34]. Along with these, Fas/FasL system has an important role in progressive renal disease and organ rejection in renal, cardiac and liver transplanta
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To explain the corporate debt maturity following Brockman et
2021-12-08
To explain the corporate debt maturity, following Brockman et al. (2010), the time-varying control variables we include are: firm size (LSIZE), the square of firm size (LSIZE2), leverage (LEVERAGE), asset maturity (ASSET_MAT), managerial ownership (OWN), market-to-book ratio (MB), term structure of
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Fatty acid amide hydrolase FAAH is a membrane bound
2021-12-08
Fatty AICAR phosphate mg amide hydrolase (FAAH) is a membrane-bound enzyme which releases arachidonic acid and ethanolamine by breaking amide bond of AEA. It also controls the cellular uptake of AEA, by creating and maintaining an inward concentration gradient leading to AEA-facilitated diffusion v
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In this review we focus on the
2021-12-07
In this review, we focus on the structure and function of the KDM4A protein, its role in cancer development, and the importance of this enzyme as a therapeutic target. For further review of the KDM4 family, see Shi et al., Whetstine et al., and Berry et al. , , . KDM4A protein structure and enzymol
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Compared with the tetrazole derivative the potency of analog
2021-12-07
Compared with the tetrazole derivative , the potency of analogs – was 3- to 17-fold improved. Of the range of heterocycles prepared, 1,2,4-thiadiazol-5(4)-one and 1,3,4-oxadiazol-2(3)-one showed the best potencies of 0.52μM and 0.61μM, respectively. Introduction of a second hydrogen bond donor, su
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Introduction Glycogen synthase kinase GSK
2021-12-07
Introduction Glycogen synthase kinase-3 (GSK-3) is an enzyme playing multiple roles in animal tissues and organs, and ITD 1 is not an exception. Apart from involvement in regulation of apoptosis and survival GSK-3 influences neuronal morphology, synapse formation, memory reconsolidation in adult b
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Our study has some limitations While our
2021-12-07
Our study has some limitations. While our study provides data from a diverse multi-country setting, we did not have a sufficient sample size to investigate whether the relationship of micronutrients and CGP 35348 with CD4 recovery differed by country. We relied on measurement of deficiencies based
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To determine the functional consequences of HIV gp
2021-12-07
To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD
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