• Considering their good FAAH inhibitory activity

  2022-07-29

  

  Considering their good FAAH inhibitory activity, compounds and have been selected for an in vivo study in a DSS-induced colitis model. Specific Pathogen Free male 7weeks old C57/Bl6 mice received 2.5% DSS in drinking water during 8days. Concomitantly, they were administrated daily intraperitoneall

• br Conclusions H K demethylases perform an

  2022-07-28

  

  Conclusions H3K27 demethylases perform an important catalytic function in mediating change in gene expression, whether it is during cell differentiation or activation, because they remove repressive marks from histones which opens the chromatin and facilitates transcription. The number of publica

• br Conclusions H K demethylases perform an

  2022-07-28

  

  Conclusions H3K27 demethylases perform an important catalytic function in mediating change in gene expression, whether it is during cell differentiation or activation, because they remove repressive marks from histones which opens the chromatin and facilitates transcription. The number of publica

• br Discussion This study dedicated

  2022-07-28

  

  Discussion This study, dedicated to Ghrelin (rat) receptor H3 and H4 receptors, was carried out on superfused tissues preincubated with 3H-choline or 3H-noradrenaline; electrical stimulation was used to elicit quasi-physiological exocytotic release of the respective transmitter. Since inhibition

• Neuromedin B australia br Introduction The role of histamine

  2022-07-28

  

  Introduction The role of histamine in allergic responses, anaphylaxis, and gastric Neuromedin B australia secretion has been well described in both human and veterinary medicine. New roles for histamine and its receptors, however, have been elucidated over the last two decades (Smuda and Bryce,

• Oltipraz has been shown to inhibit the growth of

  2022-07-28

  

  Oltipraz has been shown to inhibit the growth of HCC AG-221 and is being evaluated in clinical trials as a potential anti-cancer drug for HCC (Mann et al., 2009; Piton et al., 2005; Yates and Kensler, 2007). The present observation that pre-treatment of tumorigenic liver cells with oltipraz causes

• It is noticeable that CO as well as H

  2022-07-28

  

  It is noticeable that CO as well as H. pylori suppresses apoptosis while it induces autophagy in AGS cells. The differential effects of CO on the activation of transcription factors responsible for regulating expression of apoptosis- and autophagy-related genes merit further investigation. In concl

• br Materials and methods br

  2022-07-27

  

  Materials and methods Results Discussion An HMC is a blinding type of cataract frequently observed in Asian countries due to the appallingly high incidence of high myopia in those areas [4], [5] and typically features earlier onset and more rapid progression of nuclear cataract [1], [2]. Th

• br Discussion In the present

  2022-07-27

  

  Discussion In the present paper it was shown for the first time that the conjugation of ethacrynic PPADS tetrasodium salt synthesis and glutathione catalyzed by GSTP1-1 stereospecifically forms one of the diastereoisomers of the glutathione conjugate (EASG). Chemical conjugation results in forma

• GPR detection by reverse transcription polymerase chain

  2022-07-27

  

  GPR35 detection by reverse transcription-polymerase chain reaction (RT-PCR). Total RNA of cultured DRG neurons was extracted using the RNAqueous kit (Ambion). Complementary DNA (cDNA) was synthesized from 1μg of isolated total RNA with SuperScript III reverse transcriptase (Invitrogen). An aliquot o

• br Introduction Inflammatory bowel diseases IBDs

  2022-07-27

  

  Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis (Baumgart and Sandborn, 2012; Beaugerie et al., 2006) are typically characterized by chronic, progressive, and relapsing inflammation of the intestine. Although the exact pathogenesis of IBD is unknow

• Reports of hyperlocomotion after administration of ALX

  2022-07-27

  

  Reports of hyperlocomotion after administration of ALX-5407 [27] coupled with the lack of hyperlocomotion after administration of SSR504734, a non-sarcosine, long-residence time, competitive inhibitor [19], suggested that the GlyT1 inhibitor chemotype may impact OP. Furthermore, a compound with a co

• The discovery that GLUT in the microvasculature represents a

  2022-07-27

  

  The discovery that GLUT1 in the microvasculature represents an important target of VEGF thereby affecting Afuresertib function is highly relevant. The work of Jais et al. identified VEGF as a determining player in the regulation of cognitive performance and provides an important link to the unfavor

• The regulation of casein expression during

  2022-07-27

  

  The regulation of casein expression during lactation is a complex process involving a coordinated response at several levels. A variety of hormones are known to play roles in lactogenesis, such as prolactin (PRL), insulin, and hydrocortisone, and there is now increasing evidence that growth factors,

• In this study we demonstrate

  2022-07-27

  

  In this study, we demonstrate that the ETS transcription factor ETV5 is involved in the regulation of ghrelin system in response to the altered nutritional state. In the recent multiple GWAS studies, three single nucleotide polymorphisms (SNPs) of ETV5, rs7647305 (Thorleifsson et al., 2009; Willer e

14920 records 400/995 page Previous Next First page 上5页 396397398399400 下5页 Last page